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Journal article

BH4 increases nNOS Activity and preserves left ventricular function in diabetes

Abstract:

Rationale: In diabetic patients, heart failure with predominant left ventricular (LV) diastolic dysfunction is a common complication for which there is no effective treatment. Oxidation of the NOS (nitric oxide synthase) cofactor tetrahydrobiopterin (BH4) and dysfunctional NOS activity have been implicated in the pathogenesis of the diabetic vascular and cardiomyopathic phenotype.
Objective: Using mice models and human myocardial samples, we evalua... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/circresaha.120.316656

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0002-7440-2964
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British Heart Foundation More from this funder
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
Circulation Research Journal website
Volume:
128
Issue:
5
Pages:
585–601
Publication date:
2021-01-26
Acceptance date:
2021-01-25
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Pmid:
33494625
Language:
English
Keywords:
Pubs id:
1159093
Local pid:
pubs:1159093
Deposit date:
2021-04-16

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