Journal article
A role for the cortex in sleep–wake regulation
- Abstract:
- Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Supplementary materials, 2.3MB)
-
(Accepted manuscript, 3.2MB)
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- Publisher copy:
- 10.1038/s41593-021-00894-6
Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Neuroscience Journal website
- Volume:
- 24
- Issue:
- 9
- Pages:
- 1210–1215
- Publication date:
- 2021-08-02
- Acceptance date:
- 2021-06-23
- DOI:
- EISSN:
-
1546-1726
- ISSN:
-
1097-6256
- Pmid:
-
34341585
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1190407
- Local pid:
- pubs:1190407
- Deposit date:
- 2021-09-23
Terms of use
- Copyright holder:
- Krone et al.
- Copyright date:
- 2021
- Rights statement:
- © The Author(s), under exclusive licence to Springer Nature America, Inc. 2021.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer Nature at https://doi.org/10.1038/s41593-021-00894-6
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