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Journal article

A role for the cortex in sleep–wake regulation

Abstract:
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41593-021-00894-6

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Role:
Author
ORCID:
0000-0002-5535-7221
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Neuroscience Journal website
Volume:
24
Issue:
9
Pages:
1210–1215
Publication date:
2021-08-02
Acceptance date:
2021-06-23
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
Pmid:
34341585
Language:
English
Keywords:
Pubs id:
1190407
Local pid:
pubs:1190407
Deposit date:
2021-09-23

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