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A BEST example of channel structure annotation by molecular simulation

Abstract:

An increasing number of ion channel structures are being determined. This generates a need for computational tools to enable functional annotation of channel structures. However, a number of studies of ion channel and model pores have indicated that the physical dimensions of a pore are not always a reliable indicator of its conductive status. This is due to the unusual behavior of water within nano-confined spaces, resulting in a phenomenon referred to as ‘hydrophobic gating’. We have recent...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1080/19336950.2017.1306163

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Christ Church
Role:
Author
Wellcome Trust More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
Channels Journal website
Volume:
11
Issue:
4
Pages:
347-353
Publication date:
2017-03-20
Acceptance date:
2017-03-09
DOI:
EISSN:
1933-6969
ISSN:
1933-6950
Source identifiers:
685787
Pubs id:
pubs:685787
UUID:
uuid:45150662-a208-4a9e-bc5a-156530f181e8
Local pid:
pubs:685787
Deposit date:
2017-03-15

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