Chemical and biological studies on human oxygenases

Thesis

As depicted in Chapter I, 2-oxoglutarate- (2OG) dependent oxygenases are ubiquitous in living systems and display a wide range of cellular functions, spanning metabolism, transcription, and translation. Although functionally diverse, the 2OG oxygenases share a high degree of structural similarities between their catalytic sites. From a medicinal chemistry point of view, the combination of biological diversity and structural similarity presents a rather challenging task for the development ...

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Authors: Thinnes, C; Dr Cyrille C. Thinnes

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: platform; 2-oxoglutarate; prostate; demethylase; breast; non-haem; muscular dystrophy; chemical probe; KDM; translation; technology; cystic fibrosis; open; organasational capability; ribosome; collaboration; innovation; market; cancer; transcription; lung; OGFOD1; histone; epigenetics; iron; 2OG; oxygenase
• Subjects: Business; Organic chemistry; Marketing; Life Sciences; Entrepreneurship; Oncology; Organic synthesis; Biochemistry; Cell Biology (see also Plant sciences); Pharmacology; Management; Enzymes; Chemistry & allied sciences; Genetics (life sciences); Biophysical chemistry; Computer aided molecular and material design; Biology; Protein chemistry; Polymers Amino acid and peptide chemistry; Synthetic organic chemistry; Science and technology (business & management); Structural genomics; Business and Management; Chemical biology; Chemical kinetics; Physical Sciences