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Journal article

Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection.

Abstract:

The complement cascade defines an important link between the innate and the specific immune system. Here we show that mice deficient for the third component of complement (C3-/- mice) are highly susceptible to primary infection with influenza virus. C3-/- mice showed delayed viral clearance and increased viral titers in lung, whereas mice deficient for complement receptors CR1 and CR2 (Cr2-/- mice) cleared the infection normally. Priming of T-helper cells and cytotoxic T cells (CTLs) in lung-...

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Publication status:
Published

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Publisher copy:
10.1038/nm0402-373

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Journal:
Nature medicine
Volume:
8
Issue:
4
Pages:
373-378
Publication date:
2002-04-01
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Source identifiers:
469154

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