Thesis icon

Thesis

A study of the phenotype and function of HLA-C restricted CD8 T cells in HIV-1 infection

Abstract:

A recent study showed that a polymorphism ~35kb upstream of the HLA-C gene (-35 SNP) correlates with host control of HIV-1 in Caucasians, with the minor allele (C) associating with significantly lower set point viral loads than the major allele (T). A link between viral load and HLA-C is suggested by linkage of the two SNP alleles with different HLA-C alleles and by the fact that HLA-C, in contrast to HLA-A and -B, is not down-regulated by HIV-1 Nef protein. In addition, the -35C variant...

Expand abstract

Actions


Access Document


Files:
  • (Dissemination version, pdf, 3.7MB)

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
St Cross College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:456f2b57-55de-42ed-83ac-bcbd1d869bd0
Local pid:
ora:6648
Deposit date:
2013-01-11

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP