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Thesis

Design and analysis of genome-wide association studies

Abstract:

Despite many years of effort, linkage and candidate gene association studies have yielded disappointingly few risk loci for common human diseases such as diabetes, auto-immune disorders and cancers. Large sample sizes, increased understanding of the patterns of correlation in genetic variation, and plunging genotyping costs have enabled genome-wide association studies, which have good power to detect common risk alleles of modest effect. I present an evaluation of SNP choice in study design a...

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Oxford college:
Brasenose College
Role:
Author

Contributors

Division:
MPLS
Department:
Statistics
Role:
Supervisor
Division:
MPLS
Department:
Statistics
Role:
Supervisor
Publication date:
2008
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:45790b5c-e50c-406a-bb3c-a96868b11a28
Local pid:
ora:6011
Deposit date:
2012-01-12

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