Thesis
Design and analysis of genome-wide association studies
- Abstract:
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Despite many years of effort, linkage and candidate gene association studies have yielded disappointingly few risk loci for common human diseases such as diabetes, auto-immune disorders and cancers. Large sample sizes, increased understanding of the patterns of correlation in genetic variation, and plunging genotyping costs have enabled genome-wide association studies, which have good power to detect common risk alleles of modest effect. I present an evaluation of SNP choice in study design a...
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Authors
Contributors
+ Donnelly, P
Division:
MPLS
Department:
Statistics
Role:
Supervisor
+ Cardon, L
Division:
MPLS
Department:
Statistics
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2008
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:45790b5c-e50c-406a-bb3c-a96868b11a28
- Local pid:
- ora:6011
- Deposit date:
- 2012-01-12
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