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Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles.

Abstract:

Systemic inflammatory responsiveness was studied in normal human pregnancy and its specific inflammatory disorder, pre-eclampsia. Compared with nonpregnancy, monocytes were primed to produce more TNF-alpha throughout normal pregnancy, more IL-12p70 in the first and second trimesters, and more IL-18 in the first trimester only. Intracellular cytokine measurements (TNF-alpha and IL12p70) showed little change by comparison. IFN-gamma production was suppressed in all three trimesters. In pre-ecla...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.178.9.5949

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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
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Journal:
Journal of Immunology
Volume:
178
Issue:
9
Pages:
5949-5956
Publication date:
2007-05-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
248219
Language:
English
Keywords:
Pubs id:
pubs:248219
UUID:
uuid:46b8c0c1-51e2-4862-a33e-215179d94324
Local pid:
pubs:248219
Deposit date:
2013-11-16

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