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Journal article

Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth

Abstract:

Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key Notch ligands implicated in tumour angiogenesis. They were shown to have opposite effects on mouse retinal and adult regenerative angiogenesis. In tumours, both ligands are upregulated but their relative effects and interactions in tumour biology, particularly in tumour response to therapeutic intervention are unclear. Here we demonstrate that DLL4 and JAG1 displayed equal potency in stimulating Notch target genes in HMEC-1 endothelial cells ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/oncotarget.16969

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Funding agency for:
Oon, C
Grant:
1001/CIPPM/812156
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Funding agency for:
Oon, C
Grant:
1001/CIPPM/812156
Cancer Research UK More from this funder
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Grant:
6th Framework Grant Angiotargeting
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Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
8
Issue:
25
Pages:
40115-40131
Publication date:
2017-04-08
Acceptance date:
2017-03-11
DOI:
ISSN:
1949-2553
Language:
English
Keywords:
Pubs id:
pubs:691994
UUID:
uuid:46d89db9-e14d-4ef3-8556-e8570009da98
Local pid:
pubs:691994
Deposit date:
2017-06-14

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