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Journal article

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Abstract:

We have developed a novel real-time quaking-induced conversion RT-QuICbased assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson’s disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson’s disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patient...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/acn3.338

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Department of Health More from this funder
Publisher:
Wiley Publisher's website
Journal:
Annals of Clinical and Translational Neurology Journal website
Volume:
3
Issue:
10
Pages:
812-818
Publication date:
2016-08-01
Acceptance date:
2016-07-12
DOI:
ISSN:
2328-9503
Source identifiers:
648554
Pubs id:
pubs:648554
UUID:
uuid:46dc2a4a-9b54-4058-bd38-52baca481aea
Local pid:
pubs:648554
Deposit date:
2016-10-10

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