Journal article
Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction.
- Abstract:
-
OBJECTIVE: Galectin-3 (Gal-3) is a 26-kDa lectin known to regulate many aspects of inflammatory cell behavior. We assessed the hypothesis that increased levels of Gal-3 contribute to atherosclerotic plaque progression by enhancing monocyte chemoattraction through macrophage activation. METHODS AND RESULTS: Gal-3 was found to be upregulated in unstable plaque regions of carotid endarterectomy (CEA) specimens compared with stable regions from the same patient (3.2-fold, P<0.05) at the mRNA ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/atvbaha.107.159160
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Bibliographic Details
- Journal:
- Arteriosclerosis, thrombosis, and vascular biology
- Volume:
- 28
- Issue:
- 3
- Pages:
- 433-440
- Publication date:
- 2008-03-01
- DOI:
- EISSN:
-
1524-4636
- ISSN:
-
1079-5642
- Source identifiers:
-
24844
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:24844
- UUID:
-
uuid:473529e7-a98c-474f-a1aa-b87e6c273cd1
- Local pid:
- pubs:24844
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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