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Cancer outcomes and all-cause mortality in adults allocated to metformin: Systematic review and collaborative meta-analysis of randomised clinical trials

Abstract:

Aims/hypothesis: Observational studies suggest that metformin may reduce cancer risk by approximately one-third. We examined cancer outcomes and all-cause mortality in published randomised controlled trials (RCTs). Methods: RCTs comparing metformin with active glucose-lowering therapy or placebo/usual care, with minimum 500 participants and 1-year follow-up, were identified by systematic review. Data on cancer incidence and all-cause mortality were obtained from publications or by contacting ...

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Publisher copy:
10.1007/s00125-012-2653-7

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
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Journal:
Diabetologia
Volume:
55
Issue:
10
Pages:
2593-2603
Publication date:
2012-10-01
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
Source identifiers:
352678
Language:
English
Keywords:
Pubs id:
pubs:352678
UUID:
uuid:473ae8f6-8cf2-4687-b9f6-aab1c26fdf2a
Local pid:
pubs:352678
Deposit date:
2012-12-19

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