Journal article icon

Journal article

Similar active genes cluster in specialized transcription factories

Abstract:

How transcription affects the way specific genes are arranged within the nucleus remains to be fully understood. We examine here whether transcription occurs in discrete sites (factories) containing the required machinery and whether these sites specialize in transcribing different genes. We cotransfected plasmids encoding a common origin of replication but different transcription units into cells, where they are assembled into minichromosomes that the cellular machinery replicates and transc...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1083/jcb.200710053

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
181
Issue:
4
Pages:
615-623
Publication date:
2008-05-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Language:
English
Keywords:
Subjects:
UUID:
uuid:47404948-0d95-47a8-aaa7-55c128f75095
Local pid:
ora:4093
Deposit date:
2010-08-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP