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Pharmacokinetic study of rectal artesunate in children with severe malaria in Africa

Abstract:

When severe malaria is suspected in children, WHO recommends pre-treatment with a single rectal dose of artesunate before referral to an appropriate facility. This was an individually randomized, open-label, 2-arm, cross-over clinical trial in 83 Congolese children with severe falciparum malaria, to characterize the pharmacokinetics of rectal artesunate. At admission, children received a single dose of rectal artesunate (10 mg/kg) followed 12 hours later by intravenous artesunate (2.4 mg/kg) ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.02223-20

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0003-1932-9562
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
65
Issue:
4
Article number:
e02223-20
Publication date:
2021-03-18
Acceptance date:
2021-01-14
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Language:
English
Keywords:
Pubs id:
1159245
Local pid:
pubs:1159245
Deposit date:
2021-02-09

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