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Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1)

Abstract:

Background: Asthma is a common, chronic inflammatory airway disease of major public health importance with multiple genetic determinants. Previously, we found by positional cloning that PHD finger protein 11 (PHF11) on chromosome 13q14 modifies serum immunoglobulin E (IgE) concentrations and asthma susceptibility. No coding variants in PHF11 were identified. Objective: Here we investigate the 3 single nucleotide polymorphisms (SNPs) in this gene most significantly associated with total serum ...

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Publisher copy:
10.1016/j.jaci.2010.12.015

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Journal:
Journal of Allergy and Clinical Immunology
Volume:
127
Issue:
4
Publication date:
2011-04-01
DOI:
ISSN:
0091-6749
Source identifiers:
139053
Language:
English
Keywords:
Pubs id:
pubs:139053
UUID:
uuid:4765f1e3-8fdd-4320-a178-15ac820603c8
Local pid:
pubs:139053
Deposit date:
2012-12-19

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