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Journal article

High-resolution evolutionary analysis of within-host hepatitis C virus infection

Abstract:

Background Despite recent breakthroughs in treatment of hepatitis C virus (HCV) infection, we have limited understanding of how virus diversity generated within individuals impacts the evolution and spread of HCV variants at the population scale. Addressing this gap is important for identifying the main sources of disease transmission and evaluating the risk of drug-resistance mutations emerging and disseminating in a population.

Method

We have undertaken a high-resolution analy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/infdis/jiy747

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
BDI-NDM
Role:
Author
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
219
Issue:
11
Pages:
1722–1729
Publication date:
2019-01-02
Acceptance date:
2018-12-28
DOI:
EISSN:
1537-6613
ISSN:
1537-6613
Pmid:
30602023
Language:
English
Keywords:
Pubs id:
pubs:956037
UUID:
uuid:477da010-3aed-47d6-b418-a4a829a330af
Local pid:
pubs:956037
Deposit date:
2019-01-09

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