Journal article
The influence of catalysis on Mad2 activation dynamics
- Abstract:
-
Mad2 is a key component of the spindle assembly checkpoint, a safety device ensuring faithful sister chromatid separation in mitosis. The target of Mad 2 is Cdc20, an activator of the anaphase-promoting complex/cyclosome (APC/C). Mad2 binding to Cdc20 is a complex reaction that entails the conformational conversion Mad2 from an open (O-Mad2) to a closed (C-Mad2) conformer. Previously, it has been hypothesized that the conversion of O-Mad2 is accelerated by its conformational dimerization with...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1371/journal.pbio.1000010
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Authors
Funding
+ "Association for International Cancer Research (AICR)", "Italian Association for Cancer Research (AIRC)", "Fondo di Investimento per la Ricerca di Base (FIRB)"
More from this funder
Funding agency for:
Musacchio, A
+ "Italian Association for Cancer Research (AIRC)", "National Institutes for Health"
More from this funder
Funding agency for:
Ciliberto, A
Grant:
"1-R01-GM079207-01"
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Biology Journal website
- Volume:
- 7
- Issue:
- 1
- Article number:
- e1000010
- Publication date:
- 2009-01-01
- DOI:
- EISSN:
-
1545-7885
- ISSN:
-
1544-9173
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:477fb2c1-3204-4f94-8de9-52db10dcd6e3
- Local pid:
- ora:2720
- Deposit date:
- 2009-03-24
Related Items
Terms of use
- Copyright holder:
- Simonetta et al
- Copyright date:
- 2009
- Notes:
- Citation: Simonetta, M. et al. (2009). 'The influence of catalysis on Mad2 activation dynamics', PLoS Biology 7(1): e1000010. doi: 10.1371/journal.pbio.1000010 [Available at http://biology.plosjournals.org/]. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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