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The influence of catalysis on Mad2 activation dynamics

Abstract:

Mad2 is a key component of the spindle assembly checkpoint, a safety device ensuring faithful sister chromatid separation in mitosis. The target of Mad 2 is Cdc20, an activator of the anaphase-promoting complex/cyclosome (APC/C). Mad2 binding to Cdc20 is a complex reaction that entails the conformational conversion Mad2 from an open (O-Mad2) to a closed (C-Mad2) conformer. Previously, it has been hypothesized that the conversion of O-Mad2 is accelerated by its conformational dimerization with...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pbio.1000010

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Institution:
"European Institute of Oncology, Milan, Italy"
Department:
Department of Experimental Oncology
Role:
Author
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Institution:
"IFOM, Istituto FIRC di Oncologia Molecolare, Milan, Italy"
Role:
Author
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Institution:
"IFOM, Istituto FIRC di Oncologia Molecolare, Milan, Italy"
Role:
Author
More by this author
Institution:
"European Institute of Oncology, Milan, Italy"
Department:
Department of Experimental Oncology
Role:
Author
More by this author
Institution:
"European Institute of Oncology, Milan, Italy"
Department:
Department of Experimental Oncology
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
7
Issue:
1
Article number:
e1000010
Publication date:
2009-01-01
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Language:
English
Keywords:
Subjects:
UUID:
uuid:477fb2c1-3204-4f94-8de9-52db10dcd6e3
Local pid:
ora:2720
Deposit date:
2009-03-24

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