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Elucidating the drug release from metal–organic framework nanocomposites via In situ synchrotron microspectroscopy and theoretical modeling

Abstract:

Nanocomposites comprising metal–organic frameworks (MOFs) embedded in a polymeric matrix are promising carriers for drug delivery applications. While understanding the chemical and physical transformations of MOFs during the release of confined drug molecules is challenging, this is central to devising better ways for controlled release of therapeutic agents. Herein, we demonstrate the efficacy of synchrotron microspectroscopy to track the in situ release of 5-fluorouracil (5-FU) anticancer d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acsami.9b21321

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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
St John's College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
Balliol College
Role:
Author
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Publisher:
American Chemical Society Publisher's website
Journal:
ACS Applied Materials and Interfaces Journal website
Volume:
12
Issue:
4
Pages:
5147-5156
Publication date:
2020-01-06
Acceptance date:
2020-01-06
DOI:
EISSN:
1944-8252
ISSN:
1944-8244
Pmid:
31904920

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