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Journal article

Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa.

Abstract:

BACKGROUND: Vaccination with a recombinant modified vaccinia Ankara expressing antigen 85A from Mycobacterium tuberculosis, MVA85A, induces high levels of cellular immune responses in UK volunteers. We assessed the safety and immunogenicity of this new vaccine in West African volunteers. METHODS AND FINDINGS: We vaccinated 21 healthy adult male subjects (11 BCG scar negative and 10 BCG scar positive) with MVA85A after screening for evidence of prior exposure to mycobacteria. We monitored them...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0002921

Authors


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NIHR Oxford Biomedical Research Centre programme More from this funder
Medical Research Council More from this funder
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Grant:
AFTBVAC-ICA4-CT-2002-10052
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
3
Issue:
8
Article number:
e2921
Publication date:
2008-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
54825

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