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Combined flow cytometry and high-throughput image analysis for the study of essential genes in Caenorhabditis elegans

Abstract:
Background Advances in automated image-based microscopy platforms coupled with high-throughput liquid workflows have facilitated the design of large-scale screens utilising multicellular model organisms such as Caenorhabditis elegans to identify genetic interactions, therapeutic drugs or disease modifiers. However, the analysis of essential genes has lagged behind because lethal or sterile mutations pose a bottleneck for high-throughput approaches, and a systematic way to ana... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12915-018-0496-5

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Grant:
FP7‑PEOPLE‑2013‑IEF/GA Nr: 627263
BIOSS Centre for Biological Signalling Studie More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Biology Journal website
Volume:
16
Issue:
1
Article number:
36
Publication date:
2018-03-29
Acceptance date:
2018-02-06
DOI:
ISSN:
1741-7007
Pmid:
29598825
Source identifiers:
833483
Language:
English
Keywords:
Pubs id:
pubs:833483
UUID:
uuid:47b5f046-061f-4909-887a-0b4b56d04423
Local pid:
pubs:833483
Deposit date:
2018-04-16

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