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Thesis

The study of the deubiquitinase USP8 in Parkinson’s disease Pathogenesis

Abstract:

Parkinson's disease is the second commonest neurodegenerative disease currently treated symptomatically. It is a multifactorial disease involving mechanisms ranging from protein aggregation to mitochondrial dysfunction, oxidative stress and dopamine dysregulation. The levels of α-synuclein have been causatively linked to the development and progression of Parkinson's disease. Therefore α-synuclein lowering strategies are valid approaches in Parkinson's disease. Neuropathologically, Lewy Bo...

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Division:
MSD
Department:
Clinical Neurosciences
Department:
Nuffield Department of Clinical Neurosciences
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
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UUID:
uuid:47c2941b-5232-4bd0-92fa-e59aac16af7c
Deposit date:
2017-09-15

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