Journal article icon

Journal article

Separating speed and ability to displace roadblocks during DNA translocation by FtsK

Abstract:

FtsK translocates dsDNA directionally at > 5 kb/s, even under strong forces. In vivo, the action of FtsK at the bacterial division septum is required to complete the final stages of chromosome unlinking and segregation. Despite the availability of translocase structures, the mechanism by which ATP hydrolysis is coupled to DNA translocation is not understood. Here, we use covalently linked translocase subunits to gain insight into the DNA translocation mechanism. Covalent trimers o...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/emboj.2010.29

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
Université Paris Diderot, Paris, France
Role:
Author
More by this author
Institution:
Université Paris Diderot, Paris, France
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Expand authors...

Contributors

More from this funder
Funding agency for:
Crozat, E
More from this funder
Funding agency for:
Howarth, M
More from this funder
Funding agency for:
Vénien-Bryan, C
More from this funder
Funding agency for:
Grainge, I
Expand funders...
Publisher:
Nature Publishing Group Publisher's website
Journal:
EMBO Journal Journal website
Volume:
29
Issue:
8
Pages:
1423-1433
Publication date:
2010-04-08
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Language:
English
Keywords:
Subjects:
UUID:
uuid:47c692f7-24b5-41b0-ad7c-85460bc2aeea
Local pid:
ora:3778
Deposit date:
2010-05-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP