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Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide

Abstract:

Lipopolysaccharide (LPS) transport to the outer membrane (OM) is a crucial step in the biogenesis of microbial surface defenses. Although many features of the translocation mechanism have been elucidated, molecular details of LPS insertion via the LPS transport (Lpt) OM protein LptDE remain elusive. Here, we integrate native MS with hydrogen-deuterium exchange MS and molecular dynamics simulations to investigate the influence of substrate and peptide binding on the conformational dynamics of ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41589-020-00694-2

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0003-1820-7993
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Chemical Biology Journal website
Volume:
17
Issue:
2
Pages:
187–195
Publication date:
2020-11-16
Acceptance date:
2020-10-12
DOI:
EISSN:
1552-4469
ISSN:
1552-4450
Pmid:
33199913
Language:
English
Keywords:
Subjects:
Pubs id:
1146310
Local pid:
pubs:1146310
Deposit date:
2020-11-30

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