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MITF controls the TCA cycle to modulate the melanoma hypoxia response

Abstract:

In response to the dynamic intra‐tumor microenvironment, melanoma cells adopt distinct phenotypic states associated with differential expression of the microphthalmia‐associated transcription factor (MITF). The response to hypoxia is driven by hypoxia‐inducible transcription factors (HIFs) that reprogram metabolism and promote angiogenesis. HIF1α indirectly represses MITF that can activate HIF1α expression. Although HIF and MITF share a highly related DNA‐binding specificity, it is unclear wh...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/pcmr.12802

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Publisher:
Wiley Publisher's website
Journal:
Pigment Cell and Melanoma Research Journal website
Volume:
32
Issue:
6
Pages:
792-808
Publication date:
2019-07-08
Acceptance date:
2019-06-11
DOI:
EISSN:
1755-148X
ISSN:
1755-1471
Source identifiers:
1011756
Language:
English
Keywords:
Pubs id:
pubs:1011756
UUID:
uuid:482bc06e-2d25-4c71-9046-e151abbe37e2
Local pid:
pubs:1011756
Deposit date:
2019-06-12

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