Multiphase modelling of the influence of fluid flow and chemical concentration on tissue growth in a hollow fibre membrane bioreactor.
A 2D model is developed for fluid flow, mass transport and cell distribution in a hollow fibre membrane bioreactor. The geometry of the modelling region is simplified by excluding the exit ports at either end and focusing on the upper half of the central section of the bioreactor. Cells are seeded on a porous scaffold throughout the extracapillary space (ECS), and fluid pumped through the bioreactor via the lumen inlet and/or exit ports. In the fibre lumen and porous fibre wall, flow is descr...Expand abstract
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- Mathematical medicine and biology : a journal of the IMA
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