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Journal article

Thick blood film examination for Plasmodium falciparum malaria has reduced sensitivity and underestimates parasite density

Abstract:

Background: Thick blood films are routinely used to diagnose Plasmodium falciparum malaria. Here, they were used to diagnose volunteers exposed to experimental malaria challenge. Methods: The frequency with which blood films were positive at given parasite densities measured by PCR were analysed. The poisson distribution was used to calculate the theoretical likelihood of diagnosis. further in vitro studies used serial dilutions to prepare thick films from malaria cultures at know parasitaemi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1475-2875-5-5-104

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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More from this funder
Funding agency for:
Bejon, P
Grant:
073597
More from this funder
Funding agency for:
Hill, A
Wellcome Trust More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria journal Journal website
Volume:
5
Article number:
104
Publication date:
2006-11-01
DOI:
ISSN:
1475-2875
Language:
English
Keywords:
Subjects:
UUID:
uuid:489429dd-3a6a-47fd-a0ec-a6db36ba9cdc
Local pid:
ora:2408
Deposit date:
2008-10-29

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