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Thesis

Conformational control by intramolecular hydrogen bonding

Abstract:

Hydrogen bonds are directional, non-covalent interactions between hydrogen and electronegative atoms. Although generally weak, these interactions are critical to the stability of many biological systems including proteins and DNA. This dissertation explores small molecules in which an intramolecular hydrogen bond is the key determinant of conformation.

Chapter 1 introduces the protein Grb2 SH3C, details its role in cancer signalling, and delineates the idea of peptidomimetics—small...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Andrew D. Hamilton
Oxford college:
Oriel College
Role:
Author
More by this author
Division:
MPLS
Department:
Chemistry
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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