Thesis
Conformational control by intramolecular hydrogen bonding
- Abstract:
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Hydrogen bonds are directional, non-covalent interactions between hydrogen and electronegative atoms. Although generally weak, these interactions are critical to the stability of many biological systems including proteins and DNA. This dissertation explores small molecules in which an intramolecular hydrogen bond is the key determinant of conformation.
Chapter 1 introduces the protein Grb2 SH3C, details its role in cancer signalling, and delineates the idea of peptidomimetics—small...
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Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:48b80a00-cad2-46be-9791-5acab5761ff2
- Local pid:
- ora:7991
- Deposit date:
- 2014-02-07
Terms of use
- Copyright holder:
- James W Luccarelli
- Copyright date:
- 2013
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