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Whole-genome sequencing demonstrates that fidaxomicin is superior to vancomycin for preventing reinfection and relapse of infection with Clostridium difficile

Abstract:

Whole-genome sequencing was used to determine whether the reductions in recurrence of Clostridium difficile infection observed with fidaxomicin in pivotal phase 3 trials occurred by preventing relapse of the same infection, by preventing reinfection with a new strain, or by preventing both outcomes. Paired isolates of C. difficile were available from 93 of 199 participants with recurrences (28 were treated with fidaxomicin, and 65 were treated with vancomycin). Given C. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jit598

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
More by this author
Institution:
Optimer Pharmaceuticals
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
More by this author
Institution:
Optimer Pharmaceuticals
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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Contributors

National Institute for Health Research More from this funder
Medical Research Council More from this funder
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Publisher:
University of Chicago Press Publisher's website
Journal:
Journal of infectious diseases Journal website
Volume:
209
Issue:
9
Pages:
1446-1451
Publication date:
2013-11-11
Acceptance date:
2013-08-27
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Source identifiers:
438790
Language:
English
Keywords:
Subjects:
UUID:
uuid:48d7252a-3daa-44e3-b809-edf7c98d792a
Local pid:
pubs:438790
Deposit date:
2013-12-12

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