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Unedited in vivo detection and quantification of γ-aminobutyric acid in the occipital cortex using short-TE MRS at 3T

Abstract:

Short-TE MRS has been proposed recently as a method for the in vivo detection and quantification of γ-aminobutyric acid (GABA) in the human brain at 3T. In this study, we investigated the accuracy and reproducibility of short-TE MRS measurements of GABA at 3T using both simulations and experiments. LCModel analysis was performed on a large number of simulated spectra with known metabolite input concentrations. Simulated spectra were generated using a range of spectral linewidths and signal-to...

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Publisher copy:
10.1002/nbm.2960

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Journal:
NMR in Biomedicine
Volume:
26
Issue:
11
Pages:
1353-1362
Publication date:
2013-11-01
DOI:
EISSN:
1099-1492
ISSN:
0952-3480
Source identifiers:
436283
Language:
English
Keywords:
Pubs id:
pubs:436283
UUID:
uuid:4911ece6-4f0f-43ea-9472-d70524fded8f
Local pid:
pubs:436283
Deposit date:
2013-11-16

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