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A recurrent activating missense mutation in Waldenström macroglobulinemia affects the DNA binding of the ETS transcription factor SPI1 and enhances proliferation

Abstract:

The ETS-domain transcription factors divide into subfamilies based on protein similarities, DNA binding sequences and interaction with cofactors. They are regulated by extracellular clues and contribute to cellular processes, including proliferation and transformation. ETS genes are targeted through genomic rearrangements in oncogenesis. The PU.1/SPI1 gene is inactivated by point mutations in human myeloid malignancies. We identified a recurrent somatic mutation (Q226E) in PU.1/SPI1 in Walden...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/2159-8290.cd-18-0873

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Role:
Author
ORCID:
0000-0002-7767-755X
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Discovery Journal website
Volume:
9
Issue:
6
Publication date:
2019-04-24
Acceptance date:
2019-04-18
DOI:
EISSN:
2159-8290
ISSN:
2159-8274
Pmid:
31018969
Source identifiers:
994982
Language:
English
Keywords:
Pubs id:
pubs:994982
UUID:
uuid:4923ad77-3e17-4dc2-be7e-0606b9dac890
Local pid:
pubs:994982
Deposit date:
2019-05-07

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