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Thesis

Structural characterisation of calnexin cycle components and assessment as antiviral targets

Abstract:

N-glycosylated proteins that traverse the endoplasmic reticulum (ER) can make use of the calnexin cycle to attain their correct fold. The calnexin cycle modifies the N-glycan structure and allows for association of the glycoprotein with the ER lectins calnexin and calreticulin, which in turn recruit further chaperones that assist folding. Most enveloped viruses encode glycoproteins, which, upon infection of a host cell, crucially depend on the calnexin cycle to aid their folding. This incl...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Department:
University of Oxford
Role:
Author

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Supervisor
Role:
Examiner
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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UUID:
uuid:49322df0-e182-41a1-97ce-34aac70150fc
Deposit date:
2018-10-03

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