Journal article
Redirecting adenoviruses to tumour cells using therapeutic antibodies: generation of a versatile human bispecific adaptor
- Abstract:
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Effective use of adenovirus-5 (Ad5) in cancer therapy is heavily dependent on the degree to which the virus's natural tropism can be subverted to one that favours tumour cells. This is normally achieved through either engineering of the viral fiber knob or the use of bispecific adaptors that display both adenovirus and tumour antigen receptors. One of the main limitations of these strategies is the need to tailor each engineering event to any given tumour antigen. Here, we explore bispecific ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 513.6KB)
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- Publisher copy:
- 10.1016/j.molimm.2015.08.014
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Authors
Funding
Oxford Glycobiology Endowment
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Department of Biochemistry, University of Oxford
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Molecular immunology Journal website
- Volume:
- 68
- Issue:
- 2 Pt A
- Pages:
- 234-243
- Publication date:
- 2015-12-01
- Acceptance date:
- 2015-08-27
- DOI:
- EISSN:
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1872-9142
- ISSN:
-
0161-5890
- Source identifiers:
-
568292
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:568292
- UUID:
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uuid:4955ae90-2806-4ba4-90e5-40075d42b186
- Local pid:
- pubs:568292
- Deposit date:
- 2016-02-17
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2015
- Notes:
- Copyright © 2015 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.molimm.2015.08.014
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