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Journal article

CDKL family kinases have evolved distinct structural features and ciliary function

Abstract:

Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling and development. Neurological disorders linked to CDK-Like (CDKL) proteins suggest that these underexplored kinases may have similar functions. Here, we present the crystal structures of human CDKL1, CDKL2, CDKL3 and CDKL5, revealing their evolutionary divergence from CDK and MAPK kinases, including an unusual αJ helix importa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2017.12.083

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Genomics Consortium
Role:
Author
ORCID:
0000-0001-6757-0436
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Funding agency for:
Pelletier, L
Grant:
MOP142492
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Funding agency for:
Leroux, M
Grant:
MOP142243
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Funding agency for:
Leroux, M
Grant:
MOP142243
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
22
Issue:
4
Pages:
885-894
Publication date:
2018-01-23
Acceptance date:
2017-12-22
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Keywords:
Pubs id:
pubs:819985
UUID:
uuid:495c7a58-fdee-4a6d-babf-c7dab7b7ba1f
Local pid:
pubs:819985
Deposit date:
2018-01-16

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