Journal article icon

Journal article

Synthesis and study of novel multifunctional cyclodextrin-deferasirox hybrids

Abstract:

Metal dyshomeostasis is central to a number of disorders that result from, inter alia, oxidative stress, protein misfolding, and cholesterol dyshomeostasis. In this respect, metal deficiencies are usually readily corrected by treatment with supplements, whereas metal overload can be overcome by the use of metal‐selective chelation therapy. Deferasirox, 4‐[(3Z,5E)‐3,5‐bis(6‐oxo‐1‐cyclohexa‐2,4‐dienylidene)‐1,2,4‐triazolidin‐1‐yl]benzoic acid, Exjade, or ICL670, is used clinically to treat hemo...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1002/cmdc.201900334

Authors


Expand authors...
Niemann-Pick Research Foundation More from this funder
Publisher:
Wiley Publisher's website
Journal:
ChemMedChem Journal website
Volume:
14
Issue:
16
Pages:
1484-1492
Publication date:
2019-06-04
Acceptance date:
2019-06-03
DOI:
EISSN:
1860-7187
ISSN:
1860-7179
Source identifiers:
1008895
Language:
English
Keywords:
Pubs id:
pubs:1008895
UUID:
uuid:496c0141-e2ce-4b78-89db-9f982b269ae1
Local pid:
pubs:1008895
Deposit date:
2019-06-06

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP