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Thesis

Molecular determinants of cellular attachment-mediated zoonosis of emerging paramyxo- and arenaviruses.

Abstract:

The spillover of viral pathogens from wild animal reservoirs into human populations is the predominant cause of emerging disease events worldwide and represents an acute and persistent threat to global health, economy, and biodefence. The ability of a virus to specifically attach to cell-surface receptors during host-cell entry is a critical determinant of cross-species transmission.

Through crystallographic and biochemical analysis, this thesis presents a structural rationale for ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Supervisor
Diamond Light Source More from this funder
Wellcome Trust More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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