Molecular determinants of cellular attachment-mediated zoonosis of emerging paramyxo- and arenaviruses.
The spillover of viral pathogens from wild animal reservoirs into human populations is the predominant cause of emerging disease events worldwide and represents an acute and persistent threat to global health, economy, and biodefence. The ability of a virus to specifically attach to cell-surface receptors during host-cell entry is a critical determinant of cross-species transmission.
Through crystallographic and biochemical analysis, this thesis presents a structural rationale for ...Expand abstract
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- University of Oxford
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- Pryce, R
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