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Thesis

Investigating the role of a dynamic actin cytoskeleton and its regulators for HIV-1 entry in macrophages.

Abstract:

Macrophages are one of the three main human cell types infected by HIV-1. They are highly plastic cells requiring a dynamic actin cytoskeleton for their role in development, homeostasis, tissue repair and immunity. For HIV-1, disrupting actin in macrophages is detrimental in that it leads to a complete block of viral uptake and reduces reverse transcription but, significantly, not fusion. Rho GTPases (Rac1, RhoA and Cdc42) regulate many aspects of actin dynamics including those required fo...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
William James
Oxford college:
Brasenose College
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:497e66e0-4b67-4e0e-9616-07628e493293
Local pid:
ora:10739
Deposit date:
2015-03-27

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