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Thesis

Cell type-specific Runx1 enhancer-reporter mouse lines to study hemogenic endothelium

Abstract:

Hematopoietic stem cells emerge from a specialized subset of endothelial cells in the midgestation mouse aorta. This subset, the so-called hemogenic endothelium (HE), undergoes a morphological and molecular change to a hematopoietic cell type, as part of the endothelial-to- hematopoietic transition (EHT). Previously, lack of specific markers prevented mechanistic studies of HE, as well as studies into its developmental origin. Runx1 is a critical regulator of developmental hematopoiesis an...

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Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Department:
Clinical Laboratory Sciences
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:49b91ea8-36a3-4bcd-8842-baa1ee31c7b9
Deposit date:
2017-07-05

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