Journal article icon

Journal article

Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape

Abstract:

Defective DNA mismatch repair (dMMR) causes elevated tumour mutational burden (TMB) and microsatellite instability (MSI) in multiple cancer types. dMMR/MSI colorectal cancers (CRCs) have enhanced T cell infiltrate and favourable outcome, however this association has not been reliably detected in other tumour types, including endometrial cancer (EC). We sought to confirm this and explore the underpinning mechanisms. We first meta-analysed CRC and EC trials which have examined the prognostic va...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1002/path.5894

Authors


More by this author
Role:
Author
ORCID:
0000-0002-8195-736X
Expand authors...
Publisher:
Wiley Publisher's website
Journal:
Journal of Pathology Journal website
Volume:
257
Issue:
3
Pages:
340-351
Publication date:
2022-04-01
Acceptance date:
2022-03-07
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Language:
English
Keywords:
Pubs id:
1243143
Local pid:
pubs:1243143
Deposit date:
2022-03-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP