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The interaction between primate blood and mouse islets induces accelerated clotting with islet destruction.

Abstract:

BACKGROUND: Mouse islets transplanted under the renal subcapsular space of cynomolgus monkeys are subject to a form of hyperacute rejection, the mechanism of which is unclear. As islets are in contact with whole blood at the time of transplantation, the effect of platelets and the coagulation cascade on islet destruction was assessed. METHODS: Coagulation was assessed using thromboelastography on citrated/recalcified human blood samples with freshly isolated C57/Bl6 mouse islets. A dynamic i...

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Publication status:
Published

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Journal:
Xenotransplantation
Volume:
9
Issue:
2
Pages:
91-96
Publication date:
2002-03-01
DOI:
EISSN:
1399-3089
ISSN:
0908-665X
Source identifiers:
147405
Language:
English
Keywords:
Pubs id:
pubs:147405
UUID:
uuid:49fdb9c0-c57a-4c87-a1cc-ab1336f26e56
Local pid:
pubs:147405
Deposit date:
2012-12-19

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