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Journal article

Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime boost immunization and correlate with protection against malaria.

Abstract:

Immunological memory is a required component of protective antimalarial responses raised by T cell-inducing vaccines. The magnitude of ex vivo IFN-gamma T cell responses is widely used to identify immunogenic vaccines although this response usually wanes and may disappear within weeks. However, protection in the field is likely to depend on durable central memory T cells that are not detected by this assay. To identify longer-lived memory T cells, PBMC from malaria-naive vaccinated volunteers...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.175.9.5675

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Journal:
Journal of Immunology
Volume:
175
Issue:
9
Pages:
5675-5680
Publication date:
2005-11-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
33271
Language:
English
Keywords:
Pubs id:
pubs:33271
UUID:
uuid:4a088076-cd08-479d-ac05-87ad402af4ae
Local pid:
pubs:33271
Deposit date:
2012-12-19

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