Structure of the Lassa virus glycan shield provides a model for immunological resistance
Lassa virus is an Old World arenavirus endemic to West Africa that causes severe hemorrhagic fever. Vaccine development has focused on the envelope glycoprotein complex (GPC) that extends from the virion envelope. The often inadequate antibody immune response elicited by both vaccine and natural infection has been, in part, attributed to the abundance of N-linked glycosylation on the GPC. Here, using a virus-like-particle system that presents Lassa virus GPC in a native-like context, we deter...Expand abstract
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- Huiskonen et al
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Copyright © 2018 the Author(s). Published by PNAS.
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