Journal article
Structure of the Lassa virus glycan shield provides a model for immunological resistance
- Abstract:
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Lassa virus is an Old World arenavirus endemic to West Africa that causes severe hemorrhagic fever. Vaccine development has focused on the envelope glycoprotein complex (GPC) that extends from the virion envelope. The often inadequate antibody immune response elicited by both vaccine and natural infection has been, in part, attributed to the abundance of N-linked glycosylation on the GPC. Here, using a virus-like-particle system that presents Lassa virus GPC in a native-like context, we deter...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.6MB)
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- Publisher copy:
- 10.1073/pnas.1803990115
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Authors
Funding
Bill and Melinda Gates Foundation
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Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 115
- Issue:
- 28
- Pages:
- 7320-7325
- Publication date:
- 2018-06-25
- Acceptance date:
- 2018-06-01
- DOI:
- EISSN:
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1091-6490
- ISSN:
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0027-8424
- Source identifiers:
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859620
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:859620
- UUID:
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uuid:4a3a95c7-495a-4c21-b11d-d171350aeb56
- Local pid:
- pubs:859620
- Deposit date:
- 2018-07-09
Terms of use
- Copyright holder:
- Huiskonen et al
- Copyright date:
- 2018
- Notes:
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Copyright © 2018 the Author(s). Published by PNAS.
This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).
- Licence:
- CC Attribution (CC BY)
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