Overexpression of sarcoendoplasmic reticulum calcium ATPase 2a promotes cardiac sympathetic neurotransmission via abnormal endoplasmic reticulum and mitochondria Ca2+ regulation
Reduced cardiomyocyte excitation-contraction coupling and downregulation of the sarco-endoplasmic reticulum calcium ATPase 2a (SERCA2a) is associated with heart failure. This has led to viral transgene upregulation of SERCA2a in cardiomyocytes as a treatment. We hypothesized that SERCA2a gene therapy expressed under a similar promiscuous cytomegalovirus promoter could also affect the cardiac sympathetic neural axis and promote sympatho-excitation. Stellate neurons were isolated from 90-120g ...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 1.5MB)
- Publisher copy:
- Copyright holder:
- Shanks et al
- Copyright date:
© 2017 The Authors.
Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record