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Overexpression of sarcoendoplasmic reticulum calcium ATPase 2a promotes cardiac sympathetic neurotransmission via abnormal endoplasmic reticulum and mitochondria Ca2+ regulation

Abstract:

Reduced cardiomyocyte excitation-contraction coupling and downregulation of the sarco-endoplasmic reticulum calcium ATPase 2a (SERCA2a) is associated with heart failure. This has led to viral transgene upregulation of SERCA2a in cardiomyocytes as a treatment. We hypothesized that SERCA2a gene therapy expressed under a similar promiscuous cytomegalovirus promoter could also affect the cardiac sympathetic neural axis and promote sympatho-excitation. Stellate neurons were isolated from 90-120g ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/HYPERTENSIONAHA.116.08507

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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More from this funder
Funding agency for:
Herring, N
Grant:
FS/15/8/3115
British Heart Foundation Centre of Research Excellence, Oxford More from this funder
Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
69
Issue:
4
Pages:
625-632
Publication date:
2017-01-01
Acceptance date:
2017-01-19
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Keywords:
Pubs id:
pubs:677696
UUID:
uuid:4a49bfeb-eebe-45d7-98a9-25e98d4a6013
Local pid:
pubs:677696
Deposit date:
2017-02-08

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