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Ca2+i and the pancreatic α cell – intrinsic regulation and dysfunction in type 2 diabetes

Abstract:

In type 2 diabetes (T2D), elevated plasma glucagon concentration (hyperglucagonaemia) exacerbates hyperglycaemia due to inappropriate insulin secretion. Despite this, very little is known about why glucagon secreting α cells become dysfunctional.

In α cells, intracellular Ca2+ ([Ca2+]i) oscillations drive glucagon secretion but much of their regulation remains obscure. Here we investigate how [Ca2+]i oscillations are regulated,...

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Programme:
Ion Channels and Membrane Transport in Health and Disease (OXION)
Grant:
109115/Z/15/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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