Thesis
Notch signalling in Xenopus laevis haematopoietic stem cell programming
- Abstract:
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Multipotent haematopoietic stem cells (HSCs) originate in the dorsal aorta (DA) during vertebrate embryogenesis, and after migrating to a permanent niche, give rise to a continuous supply of mature blood cells of all lineages throughout adult life. Previous cell tracing experiments have shown that the cells of the DA migrate here from an early collection of haemangioblasts (bipotential precursors of blood and endothelial cells) which reside in the dorsolateral plate (DLP) mesoderm. Develop...
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(Dissemination version, pdf, 25.1MB)
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Authors
Contributors
+ Patient, R
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:4a6db3d9-14ec-4ad2-ad7f-06705c49d32e
- Local pid:
- ora:6800
- Deposit date:
- 2013-04-11
Terms of use
- Copyright holder:
- Stephenson, R
- Copyright date:
- 2012
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