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Understanding paratyphoid infection: study protocol for the development of a human model of Salmonella enterica serovar Paratyphi A challenge in healthy adult volunteers.

Abstract:

INTRODUCTION: This study will develop the first human challenge model of paratyphoid infection which may then be taken forward to evaluate paratyphoid vaccine candidates. Salmonella Paratyphi A is believed to cause a quarter of the estimated 20 million cases of enteric fever annually. Epidemiological evidence also suggests that an increasing proportion of the enteric fever burden is attributable to S. Paratyphi infection meriting further attention and interest in vaccine development. Assessme...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1136/bmjopen-2014-007481

Authors


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National Institute for Health Research More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ open Journal website
Volume:
5
Issue:
6
Pages:
e007481
Publication date:
2015-01-01
DOI:
EISSN:
2044-6055
ISSN:
2044-6055
Source identifiers:
527641
Language:
English
Keywords:
Pubs id:
pubs:527641
UUID:
uuid:4a6ebc4d-d236-4459-bf70-4270827a4643
Local pid:
pubs:527641
Deposit date:
2015-11-28

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