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Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.

Abstract:

Aprataxin, defective in the neurodegenerative disorder ataxia oculomotor apraxia type 1 (AOA1), is a DNA repair protein that processes the product of abortive ligations, 5' adenylated DNA. In addition to its interaction with the single-strand break repair protein XRCC1, aprataxin also interacts with poly-ADP ribose polymerase 1 (PARP-1), a key player in the detection of DNA single-strand breaks. Here, we reveal reduced expression of PARP-1, apurinic endonuclease 1 (APE1) and OGG1 in AOA1 cell...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddp359

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
Human molecular genetics
Volume:
18
Issue:
21
Pages:
4102-4117
Publication date:
2009-11-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
131138

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