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Thesis

The linear ubiquitin assembly complex’s recruitment to signaling complexes: The role of HOIP’s zinc finger domains

Abstract:

The linear ubiquitin chain assembly complex (LUBAC) regulates NF-κB activation and prevents cell death by conjugating M1 polyubiquitin on inflammatory complexes through its catalytic subunit HOIP. Although the conjugation of M1 chains is well described, less is known about the mechanism of LUBAC’s recruitment to inflammatory signaling complexes. This thesis elucidates the role of HOIP’s zinc finger region, which encompasses its B-box, Zf and NZF domains, in the binding and recruitment to ubiq...

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Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0002-7641-2103
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-09-24

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