Journal article icon

Journal article

A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo.

Abstract:

Copper(II)bis(thiosemicarbazonato) complexes such as [(64)Cu]Cu-ATSM continue to be investigated for positron emission tomography (PET) imaging of tumour hypoxia. However, the currently proposed mechanisms for the mode of action of these complexes are unable to account fully for their observed biological behaviour. In order to examine the roles of the copper metal and the ligand, we designed a pair of (123)I/(64)Cu-copper bis(thiosemicarbazonates), radiolabelled at either the metal or at the ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1039/c4mt00330f

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Hueting, R
More from this funder
Funding agency for:
Cornelissen, B
Grant:
C14521/A6245
More from this funder
Funding agency for:
Cornelissen, B
Grant:
C14521/A6245
Expand funders...
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Metallomics : integrated biometal science Journal website
Volume:
7
Issue:
5
Pages:
795-804
Publication date:
2015-01-01
DOI:
EISSN:
1756-591X
ISSN:
1756-5901
Source identifiers:
514445
Language:
English
Pubs id:
pubs:514445
UUID:
uuid:4a9aefce-13a2-4ede-a170-052c02e5b1f8
Local pid:
pubs:514445
Deposit date:
2015-11-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP