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Heat shock protein-based therapy for sphingolipidoses

Abstract:
Lysosomal diseases often manifest with severe systemic and central nervous system (CNS) symptoms. The existing treatment options are limited and have no or only modest efficacy against neurological manifestations of disease. We recently demonstrated that recombinant HSP70 improves the binding of several sphingolipid-degrading enzymes to their essential co-factor, bis(monoacylglycero)phosphate, in vitro
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ymgme.2016.11.178

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
WORLDSymposium 2017 Journal website
Host title:
WORLDSymposium 2017
Publication date:
2017-02-01
DOI:
ISSN:
1096-7192
Source identifiers:
719204
Pubs id:
pubs:719204
UUID:
uuid:4ac3bf8e-231c-4e41-9f8c-90172d2dcde0
Local pid:
pubs:719204
Deposit date:
2017-11-09

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