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The guidance receptor plexin D1 is a mechanosensor in endothelial cells

Abstract:

Shear stress on arteries produced by blood flow is important for vascular development and homeostasis but can also initiate atherosclerosis1. Endothelial cells that line the vasculature use molecular mechanosensors to directly detect shear stress profiles that will ultimately lead to atheroprotective or atherogenic responses2. Plexins are key cell-surface receptors of the semaphorin family of cell-guidance signalling proteins and can regulate cellular patterning by modulating the cytoskeleton...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1038/s41586-020-1979-4

Authors


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John Fell Fund More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
578
Pages:
290–295
Publication date:
2020-02-05
Acceptance date:
2019-12-05
DOI:
EISSN:
1476-4687
Language:
English
Pubs id:
1085992
Local pid:
pubs:1085992
Deposit date:
2020-02-13

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